Dose of Erythropoiesis-Stimulating Agents and Adverse Outcomes in CKD: A Metaregression Analysis
نویسندگان
چکیده
منابع مشابه
An economic evaluation of erythropoiesis-stimulating agents in CKD.
BACKGROUND The objective was to determine the cost-effectiveness of treating anemic patients with chronic kidney disease (CKD) with erythropoiesis-stimulating agents (ESAs) to a low (9-10.9 g/dL), intermediate (11-12 g/dL), or high (> 12 g/dL) hemoglobin level target compared with a strategy of managing anemia without ESAs. STUDY DESIGN Cost-utility analysis. SETTING & PARTICIPANTS Publicly...
متن کاملAn economic evaluation of erythropoiesis-stimulating agents in CKD
CRD summary The study assessed the cost-effectiveness of treating non-dialysis and dialysis patients with chronic kidney disease with erythropoiesis-stimulating agents (ESAs) to a low, intermediate or high haemoglobin level target. The authors concluded that targeting ESA treatment to high haemoglobin levels was not associated with overall clinical benefit and resulted in considerable additiona...
متن کاملTiming of erythropoiesis-stimulating agent initiation and adverse outcomes in nondialysis CKD: a propensity-matched observational study.
BACKGROUND AND OBJECTIVES The severity of anemia at which to initiate erythropoiesis-stimulating agent (ESA) treatment in nondialysis chronic kidney disease (CKD) patients is unclear. Risk of mortality, hospitalizations, and blood transfusion were compared among nondialysis CKD patients with "early" versus "delayed" ESA initiation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A retrospective...
متن کاملSafety and efficacy outcomes with erythropoiesis-stimulating agents in patients with breast cancer: a meta-analysis.
BACKGROUND New data on erythropoiesis-stimulating agents (ESAs) regarding overall survival and disease progression-related outcomes in patients with breast cancer receiving chemotherapy are presented in a meta-analysis of controlled trials of ESA use (epoetin α, epoetin β, darbepoetin α, biosimilars). PATIENTS AND METHODS A literature search identified reports from January 1997 through March ...
متن کاملErythropoiesis stimulating agents and reno-protection: a meta-analysis
BACKGROUND Erythropoiesis stimulating agents (ESAs) were proposed to enhance survival of renal tissues through direct effects via activation of EPO receptors on renal cells resulting in reduced cell apoptosis, or indirect effects via increased oxygen delivery due to increased numbers of Hb containing red blood cells. Thus through several mechanisms there may be benefit of ESA administration on ...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2013
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2012.07.014